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J Korean Soc Ther Radiol Oncol > Volume 29(1); 2011 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2011;29(1): 53-62. doi: https://doi.org/10.3857/jkstro.2011.29.1.53
Three Cases of Radiation-Induced Hepatitis B Virus Reactivation after Hepatic Tomotherapy: Case Report
Moonkyoo Kong, Seong Eon Hong, Byung Ho Kim, Jinhyun Choi
1Department of Radiation Oncology, Kyung Hee University College of Medicine, Seoul, Korea. anjdixn@naver.com
2Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea.
ABSTRACT
Radiation-induced liver disease (RILD) has been characterized as a veno-occlusive disease with anicteric elevation of alkaline phosphatase (ALP). However, some RILD patients present with elevated transaminase levels rather than with anicteric elevation of ALP, and these findings are common in the Asia-Pacific region where hepatitis B virus (HBV) infection is associated with 70~90% of hepatocelluar carcinoma (HCC) cases. In addition, the development of RILD is more common in patients with hepatitis B virus-related HCC. These findings indicate that susceptibility to RILD might be different in HBV carriers and non-carriers, and moreover, RILD in patients with HBV-related HCC might be associated with another unique pathogenesis such as HBV reactivation. However, HBV reactivation after hepatic irradiation has been reported in only a few studies. This study reports three cases of HBV reactivation after hepatic tomotherapy for management of HCC.
Key Words: Hepatocellular carcinoma, Tomotherapy, Hepatitis B virus reactivation
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