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Journal of the Korean Society for Therapeutic Radiology 1985;3(1): 1-8. |
| Radiation Effect on Mouse Jejunal Crypt Cells by Single and Split Irradiation |
| Byung Hee Koh, Chang Kok Hahm, Jung Jin Kim, Chan Il Park |
| Department of Radiology, College of Medicine, Seoul National University, Korea. |
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| ABSTRACT |
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To determine the dose-urvival and repair characteristics of the jejunal crypt cells, experimental study was carried out using total 70 mice. Single or split irradiations of 1,100 to 2,200 rad were delivered to whole bodies of C57 BL mice, using a cesium 137 animal irradiator and those mice were sacrificed after 90 hours. The number of regenerating crypts per jejunal circumference was counted by a jejunal crypt cell assay technique and dose-esponse curve was measured.
The results were as follows : 1. The average number of jejunal crypts per circumference in control group was 140.
In a single irradiation group, the number of regenerated jejunal crypts was, 125, 56, 2 in each subgroup of 1,100 rad, 1,400 rad and 1,800 rad respectively. In split irradiation group, it was 105, 44, 2 in each subgroup of 1,400rad 1,800rad and 2,200 rad respectively. 2. Mean lethal dose of mouse jejunal crypt cell was 167 and 169 rad respectively in a single and split irradiation. 3. Repair dose of sublethal damage was 280 rad. 4. sublethal damage was completely repaired within 4 hours between the split dose of irradiation. |
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