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J Korean Soc Ther Radiol Oncol > Volume 17(1); 1999 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 1999;17(1): 36-41.
Radiotherapy of Locally Recurrent Rectal Carcinoma
Hyeon Ju Jeong, Young Ju Shin, Kwang Mo Yang, Hyun Suk Suh, Hachung Chun, Myung Za Lee
1Department of Radiation Oncology, College of Medicine, Inje University, Paik Hospital, Korea.
2Department of Radiation Oncology, College of Medicine, Hanyang University, Seoul, Korea.
ABSTRACT
PURPOSE:
We reviewed the treatment results for the patients with locally recurrent rectal carcinoma. The object was to evaluate the treatment outcome and to identify the prognostic factors influencing the survival. METHODS AND MATERIALS: Twenty-eight patients with locally recurrent rectal carcinoma treated principally with external-beam radiation therapy between 1982 to 1996 in the Department of Radiation Oncology at Paik and Hanyang Hospital were reviewed retrospectively. Of these, 17 patients had initially abdominoperineal resection, 9 had low anterior resection, and 2 had local excision. No patients had received adjuvant radiation therapy for the primary disease. There were 14 men and 14 women whose ages ranged from 31 to 72 years (median age:54.5). Median time from initial surgery to the start of radiation therapy for local recurrence was 11 months (4~47 months). Radiation therapy was given with total doses ranging from 27 to 64.8 Gy (median=51.2 Gy).
RESULTS:
The median survival was 16.7 months. The 2-year and 5-year survival rates were 20.1%, 4.1% respectively. Upon multivariate analysis, overall survival was positively correlated with duration of intervals from initial surgery to local recurrence (P=0.039). Relief of pelvic symptoms was achieved in 17 of 28 patients (60.7%). Pain and bleeding responded in 40% and 100% of patients, respectively.
CONCLUSION:
Patients with locally recurrent rectal carcinoma treated with radiotherapy have benefited symptomatically, and might have increased survivals with a small chance of cure. But, patient were rarely cured (median survival:10 months, 5-year survival:less than 5%). Overall survival was positively correlated with long intervals from initial surgery to local recurrence. Future efforts should be directed to the use of effective therapy for patients with locally recurrent rectal carcinoma and adjuvant therapy for patients with rectal cancer to reduce the incidence of pelvic recurrence.
Key Words: Recurrence, Rectal carcinoma, Radiotherapy
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